Endocrine Abstracts

Introduction: Premature ovarian insufficiency (POI) affects approximately 1% of females. In POI, hormone replacement manages symptoms and reduces the risk of bone mineral density (BMD) loss as oestrogen acts to enhance bone deposition in bone remodelling. Oestrogen may be given either as synthetic oestrogen (ethinylestradiol) as in most combined oral contraceptives (COCP), or as physiological oestrogen (oestradiol) as in hormone replacement therapy (HRT preparations) and a sel...